Тореміфен (англ.)

Treatment of cystic lesions in breast tissue: an effectiveness of toremifene

Kovalchuk I.S., Hulchiy M.V.

Kyiv City Teaching Endocrinological Center, Kyiv, Ukraine

Cystic lesions of breast tissue are frequently diagnosed among fertile age women. Incidence of this disorder is up to 30% out of all benign disorders of the breast. Although the benign status, some of breast cysts have a proliferative potential resulting in cysts enlargement, focal pain and local discomfort. The most common cause of this condition is disturbances of sex-steroid hormone production such as estrogen. Therefore using of anti-estrogen drugs might be a useful tool in management of the breast cysts. However, little is known about the effect of estrogen-receptor blockers in treatment of women with cystic lesions of the breast.

The aim of this study was to investigate the effect of estrogen-receptor blocker toremifene on breast cysts of fertile age women.

Material and methods

We identified 94 female patients of fertile age (mean 34.5, range 29-50) with diagnosis of benign breast cysts. Two groups were established according to treatment. One group (n=46) received toremifene 20 mg/day (T) between 5th and 25th day of menstrual cycle, whereas the second group (n=48) underwent phytotherapy (P). After 3 months of treatment patients underwent interview, physical examination; the size and amount of cystic lesions were evaluated by mammography and sonography and then compared between the groups.

Results

The reduction of cystic size was 2 times higher in group T (73%, 34/46), as compared to group P (35%, 17/48), p=0.001. The number of eliminated small (≤ 7 mm) cystic lesions was also 2 times higher in group T (36%, 16/46) compared to group P (16%, 7/48), p=0.031. Our results suggest that toremifene is effective drug for treatment of breast cysts. However, further observations are needed to determine the long-time effect and justify the patinets’ outcome.

Decreasing of local symptoms was similar in both groups: T (89%, 41/46) and P (69%, 42/48).

Conclusions

Our results suggest that toremifene is effective drug for treatment of breast cysts. However, further observations are needed to determine its long-term effect

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